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Article

A leucine zipper in the N terminus confers membrane association to SLP-65.

Nature immunology - 1 Feb 2005

Köhler Fabian, Storch Bettina, Kulathu Yogesh, Herzog Sebastian, Kuppig Stephan, Reth Michael, Jumaa Hassan

Abstract excerpt

Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-65 N terminus is responsible for membrane association. Alterations in the N terminus abolished...

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Share to Carrier Proteins
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 15654340
DOI: 10.1038/ni1163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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