Article
C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations.
Cancer science - 1 Dec 2021
Kurata Morito, Onishi Iichiro, Takahara Tomoko, Yamazaki Yukari, Ishibashi Sachiko, Goitsuka Ryo, Kitamura Daisuke, Takita Junko, Hayashi Yasuhide, Largaesapda David A, Kitagawa Masanobu, Nakamura Takuro
Abstract excerpt
BLNK (BASH/SLP-65) encodes an adaptor protein that plays an important role in B-cell receptor (BCR) signaling. Loss-of-function mutations in this gene are observed in human pre-B acute lymphoblastic leukemia (ALL), and a subset of Blnk knock-out (KO) mice develop pre-B-ALL. To understand the molecular mechanism of the Blnk mutation-associated pre-B-ALL development, retroviral tagging was applied to KO mice using...
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