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Article

Isochromosome 17q Is a Negative Prognostic Factor in Poor-Risk Childhood Medulloblastoma Patients

1 Jul 2005

Abstract excerpt

BACKGROUND: Medulloblastomas are the most common primary malignant childhood intracranial neoplasms. Patients are currently sorted into three risk groups based on clinical criteria: standard, poor, and infant (<18 months old). We hypothesized that genetic copy number aberrations (CNA) predict prognosis and would provide improved criteria for predicting outcome. METHODS: DNA from 35 medulloblastoma patients from...

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PMID: 16000568
DOI: 10.1158/1078-0432.ccr-04-0465

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