Article

Keratin 17- and PKCα-dependent transient amplification of neutrophil influx after repeated stress to the skin

2023-10-14

Abstract excerpt

Neutrophils contribute to the pathogenesis of chronic inflammatory skin diseases. Little is known about the source and identity of the signals mediating their recruitment in inflamed skin. We used the phorbol ester TPA and UVB, alone or in combination, to induce sterile inflammation in mouse skin and assess whether keratinocyte-derived signals impact neutrophil recruitment. A single TPA treatment results in a neut...

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Literature Corpus work: 1e69a469-de1b-5f86-9e20-7364d5ea5f03
DOI: 10.1101/2023.10.11.561954

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