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Article

Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003

Wells Susanne I, Aronow Bruce J, Wise Trisha M, Williams Sarah S, Couget Jennifer A, Howley Peter M

Abstract excerpt

A frequent characteristic of human papillomavirus (HPV)-positive cervical cancers is the loss of viral E2 gene expression in HPV-infected cervical epithelial cells as a consequence of viral DNA integration into the cellular genome. The expression of E2 in HPV-positive cancer cells results in the repression of the viral E6/E7 oncogenes, activation of the p53 and pRB pathways, and a G1 cell cycle arrest, followed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12756294
DOI: 10.1073/pnas.1232309100
PMCID: PMC165835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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