Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.

The EMBO journal - 1 Nov 2000

Wells S I, Francis D A, Karpova A Y, Dowhanick J J, Benson J D, Howley P M

Abstract excerpt

A hallmark of human papillomavirus (HPV) associated carcinogenesis is the integration of the viral DNA into the cellular genome, usually accompanied by the loss of expression of the viral E2 gene. E2 binds to and represses the viral promoter directing expression of the E6 and E7 oncogenes. The re-introduction and expression of exogenous E2 in HPV-positive cancer cells results in cellular growth arrest, while...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclins

Share to Oligodeoxyribonucleotides, Antisense

Share to Oncogene Proteins, Viral

Share to Papillomavirus E7 Proteins

Share to Retinoblastoma Protein

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 11060027
DOI: 10.1093/emboj/19.21.5762
PMCID: PMC305788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.PMID 11060027Read ↗

E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescenceSemantic proximity Read ↗

Human Papillomavirus Type 16 E6 Promotes Retinoblastoma Protein Phosphorylation and Cell Cycle ProgressionSemantic proximity Read ↗

Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial CellsSemantic proximity Read ↗

Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life CycleSemantic proximity Read ↗

Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: Roles of E6 and E7 proteinsSemantic proximity Read ↗

Papillomavirus E6 and E7 proteins and their cellular targetsSemantic proximity Read ↗

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In VivoSemantic proximity Read ↗

Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma CellsSemantic proximity Read ↗

Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.Semantic proximity Read ↗

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve OncogenesisSemantic proximity Read ↗

Human papillomavirus type 16 E7 oncoprotein associates with E2F6.Semantic proximity Read ↗

Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in SenescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.