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A Genomic Approach Reveals a Novel Mitotic Pathway in Papillomavirus Carcinogenesis

1 Feb 2004

Abstract excerpt

More than 90% of cervical carcinomas are associated with human papillomavirus (HPV) infection. The two viral oncogenes E6 and E7 play a major role in transforming the cells by disrupting p53- and pRb-dependent cell cycle checkpoints. A hallmark of HPV-associated cervical carcinoma is loss of the expression of the viral E2 protein, often by disruption of E2-encoding gene. We showed previously that reintroduction...

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PMID: 14871818
DOI: 10.1158/0008-5472.can-03-2349

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