Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes.

Mechanisms of ageing and development - 1 Jan 2004

Kang Hyun Tae, Lee Chan Jae, Seo Eun Jeong, Bahn Young Jae, Kim Hyun Jung, Hwang Eun Seong

Abstract excerpt

Inhibition of human papillomavirus (HPV) E6 and E7 transcription by means of the E2 protein of bovine papillomavirus 1 (BPV1) has been shown to induce acute growth arrest in HPV-positive cervical carcinoma cells. This state of arrest is marked by the expression of senescence phenotypes including SA beta-Gal activity and lipofuscin accumulation. In this study, we examined the reversibility of these phenotypes by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to E2F Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Intracellular Membranes

Share to Mitogen-Activated Protein Kinases

Share to Oncogene Proteins, Viral

Share to Retinoblastoma Protein

Share to Viral Proteins

Source

Identifiers

PMID: 14706235
DOI: 10.1016/j.mad.2003.10.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes.PMID 14706235Read ↗

Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma CellsSemantic proximity Read ↗

Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.Semantic proximity Read ↗

Rapid induction of senescence in human cervical carcinoma cellsSemantic proximity Read ↗

Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in SenescenceSemantic proximity Read ↗

Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.Semantic proximity Read ↗

Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathwaysSemantic proximity Read ↗

Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.Semantic proximity Read ↗

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.Semantic proximity Read ↗

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cellsSemantic proximity Read ↗

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinSemantic proximity Read ↗

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 and E7 induces senescence in cervical cancer cellsSemantic proximity Read ↗

Repression of the Integrated Papillomavirus E6/E7 Promoter Is Required for Growth Suppression of Cervical Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.