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Article

Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state.

The Journal of pathology - 1 Nov 2013

Hanning Jennifer E, Saini Harpreet K, Murray Matthew J, Caffarel Maria M, van Dongen Stijn, Ward Dawn, Barker Emily M, Scarpini Cinzia G, Groves Ian J, Stanley Margaret A, Enright Anton J, Pett Mark R, Coleman Nicholas

Abstract excerpt

In cervical carcinomas, high-risk human papillomavirus (HR-HPV) may be integrated into host chromosomes or remain extra-chromosomal (episomal). We used the W12 cervical keratinocyte model to investigate the effects of HPV16 early gene depletion on in vitro cervical carcinogenesis pathways, partic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Viral

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Share to Oncogene Proteins, Viral

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Source

Identifiers

PMID: 23913724
DOI: 10.1002/path.4244

Genes

IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23913724-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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