Article
Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.
Molecular pharmacology - 1 Jul 2002
Lin Yvonne S, Dowling Amy L S, Quigley Sean D, Farin Federico M, Zhang Jiong, Lamba Jatinder, Schuetz Erin G, Thummel Kenneth E
Abstract excerpt
We recently demonstrated that a variant allele of CYP3A5 (CYP3A5*3) confers low CYP3A5 expression as a result of improper mRNA splicing. In this study, we further evaluated the regulation of CYP3A5 in liver and jejunal mucosa from white donors. For all tissues, high levels of CYP3A5 protein were strongly concordant with the presence of a wild-type allele of the CYP3A5 gene (CYP3A5*1). CYP3A5 represented greater...
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