DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection

Abstract excerpt

BACKGROUND: The prevalence of allergic diseases are increasing worldwide, emphasizing the need to elucidate their pathogeneses. The aims of this study were to use a two-stage design to identify DNA methylation levels at cytosine-phosphate-guanine (CpG) sites across the genome associated with atopy and high serum immunoglobulin E (IgE), then to replicate our findings in an independent cohort. METHODS: Atopy was...

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