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The HIV-1 vpr R77Q Mutant Induces Apoptosis, G2 Cell Cycle Arrest, and Lower Production of Pro-Inflammatory Cytokines in Human CD4+ T Cells.

Viruses - 21 Oct 2024

Solis-Leal Antonio, Karlinsey Dalton C, Sithole Sidney T, Lopez Jack Brandon, Carlson Amanda, Planelles Vicente, Poole Brian D, Berges Bradford K

Abstract excerpt

Acquired immunodeficiency syndrome (AIDS) occurs when HIV depletes CD4+ helper T cells. Some patients develop AIDS slowly or not at all, and are termed long-term non-progressors (LTNP), and while mutations in the HIV-1 Viral Protein R (vpr) gene such as R77Q are associated with LTNP, mechanisms for this correlation are unclear. This study examines the induction of apoptosis, cell cycle arrest, and...

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to G2 Phase Cell Cycle Checkpoints

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Share to vpr Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 39459974
DOI: 10.3390/v16101642
PMCID: PMC11512211

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