Article
AIDS pathogenesis: the role of accessory gene mutations, leading to formation of long-lived persistently infected cells and/or apoptosis-inducing HIV-1 particles.
Virus research - 1 Dec 1997
Ikuta K, Kameoka M, Luftig R B
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) infection indirectly induces activation-dependent apoptosis in bystander immune CD4+ T-cells, a hallmark of AIDS pathogenesis. It is well known that this pathogenetic event is significantly correlated with a high virus load. Active viral replication occ...
Topics
- Acquired Immunodeficiency Syndrome
- Apoptosis
- Capsid
- Capsid Proteins
- Gene Products, gag
- Gene Products, nef
- HIV-1
- Humans
- Mutation
- Time Factors
- Viral Proteins
- Virion
- Virus Integration
- Virus Latency
- gag Gene Products, Human Immunodeficiency Virus
- nef Gene Products, Human Immunodeficiency Virus