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Article

Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 13 Oct 2015

Giles Andrew C, Opperman Karla J, Rankin Catharine H, Grill Brock

Abstract excerpt

The PAM/Highwire/RPM-1 (PHR) proteins are signaling hubs that function as important regulators of neural development. Loss of function in Caenorhabditis elegans rpm-1 and Drosophila Highwire results in failed axon termination, inappropriate axon targeting, and abnormal synapse formation. Despite broad expression in the nervous system and relatively dramatic defects in synapse formation and axon development, very...

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Source

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Identifiers

PMID: 26464359
DOI: 10.1534/g3.115.021410
PMCID: PMC4683646

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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