Article
Breast cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2003
Jakubowska Anna, Narod Steven A, Goldgar David E, Mierzejewski Marek, Masojć Bartłomiej, Nej Katarzyna, Huzarska Jowita, Byrski Tomasz, Górski Bohdan, Lubiński Jan
Abstract excerpt
The observed heterogeneity of breast cancer risk among women who carry the same BRCA1 mutation suggests the existence of modifying environmental and genetic factors. The product of the RAD51 gene functions with BRCA1 and BRCA2 in the repair of double-stranded DNA breaks. To establish whether polymorphic variation of RAD51 modifies risk for hereditary breast cancer, we conducted a matched case-control study on 83...
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