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Article

ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context.

BMC bioinformatics - 20 Mar 2006

Margolin Adam A, Nemenman Ilya, Basso Katia, Wiggins Chris, Stolovitzky Gustavo, Dalla Favera Riccardo, Califano Andrea

Abstract excerpt

BACKGROUND: Elucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide "reverse engineering" of such networks have been successful only for lower eukaryotes with simple genomes. Here we present ARACNE, a novel algorithm, using microarray expression profiles, specifically designed to scale up to the...

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Identifiers

PMID: 16723010
DOI: 10.1186/1471-2105-7-S1-S7
PMCID: PMC1810318

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