ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context.

doi:10.1186/1471-2105-7-S1-S7

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Article

ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context.

BMC bioinformatics - 20 Mar 2006

Margolin Adam A, Nemenman Ilya, Basso Katia, Wiggins Chris, Stolovitzky Gustavo, Dalla Favera Riccardo, Califano Andrea

Abstract excerpt

BACKGROUND: Elucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide "reverse engineering" of such networks have been successful only for lower eukaryotes with simple genomes. Here we present ARACNE, a novel algorithm, using microarray expression profiles, specifically designed to scale up to the...

Topics

Algorithms
Animals
B-Lymphocytes
Computational Biology
Computer Simulation
Gene Expression Profiling
Gene Expression Regulation
Humans
Models, Statistical
Neural Networks, Computer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Array Sequence Analysis

Phenotype

Proto-Oncogene Mas

Reproducibility of Results

Software

Transcription, Genetic

Source

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Identifiers

PMID: 16723010
DOI: 10.1186/1471-2105-7-S1-S7
PMCID: PMC1810318

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