Article
Trans allele methylation and paramutation-like effects in mice.
Nature genetics - 1 Jun 2003
Herman Herry, Lu Michael, Anggraini Melly, Sikora Aimee, Chang Yanjie, Yoon Bong June, Soloway Paul D
Abstract excerpt
In mammals, imprinted genes have parent-of-origin-specific patterns of DNA methylation that cause allele-specific expression. At Rasgrf1 (encoding RAS protein-specific guanine nucleotide-releasing factor 1), a repeated DNA element is needed to establish methylation and expression of the active paternal allele. At Igf2r (encoding insulin-like growth factor 2 receptor), a sequence called region 2 is needed for...
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