Article
Shared role for differentially methylated domains of imprinted genes.
Molecular and cellular biology - 1 Apr 2002
Reinhart Bonnie, Eljanne Mariam, Chaillet J Richard
Abstract excerpt
For most imprinted genes, a difference in expression between the maternal and paternal alleles is associated with a corresponding difference in DNA methylation that is localized to a differentially methylated domain (DMD). Removal of a gene's DMD leads to a loss of imprinting. These observations suggest that DMDs have a determinative role in genomic imprinting. To examine this possibility, we introduced sequences...
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