Article
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.
The Journal of nutrition - 1 Apr 2003
tom Dieck Heike, Döring Frank, Roth Hans-Peter, Daniel Hannelore
Abstract excerpt
Zinc deficiency affects hepatic functions and due to the central role of the liver in metabolism, this may contribute to metabolic alterations in other tissues in zinc deficiency. In addition to clinical manifestations of zinc deficiency, we used cDNA- and oligonucleotide-arrays to compare the expression of > 2500 different genes in liver of rats force-fed a zinc-adequate or a zinc-deficient diet for 11 d. Radio-...
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