Article
Guanidine reduces stop codon read-through caused by missense mutations in SUP35 or SUP45.
Yeast (Chichester, England) - 1 May 2003
Bradley Michael E, Bagriantsev Sviatoslav, Vishveshwara Namitha, Liebman Susan W
Abstract excerpt
Sup35 and Sup45 are essential protein components of the Saccharomyces cerevisiae translation termination factor. Yeast cells harbouring the [PSI(+)] prion form of Sup35 have impaired stop codon recognition (nonsense suppression). It has long been known that the [PSI(+)] prion is not stably transmitted to daughter cells when yeast are grown in the presence of mM concentrations of guanidine hydrochloride (GuHCl)....
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