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Article

Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure.

American journal of physiology. Cell physiology - 1 Feb 2010

Kubo Eri, Hasanova Nailia, Tanaka Yukie, Fatma Nigar, Takamura Yoshihiro, Singh Dhirendra P, Akagi Yoshio

Abstract excerpt

Oxidative stress is one of the causative factors in progression and etiology of age-related cataract. Peroxiredoxin 6 (Prdx6), a savior for cells from internal or external environmental stresses, plays a role in cellular signaling by detoxifying reactive oxygen species (ROS) and thereby controlling gene regulation. Using targeted inactivation of the Prdx6 gene, we show that Prdx6-deficient lens epithelial cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Hydrogen Peroxide

Share to Lens, Crystalline

Share to Peptide Mapping

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Tropomyosin

Source

Open in PubMed Open full text

Identifiers

PMID: 19889963
DOI: 10.1152/ajpcell.00336.2009
PMCID: PMC2822493

Genes

PRDX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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