Article
Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study.
Archives of neurology - 1 Jun 2006
Sun Mei, Latourelle Jeanne C, Wooten G Frederick, Lew Mark F, Klein Christine, Shill Holly A, Golbe Lawrence I, Mark Margery H, Racette Brad A, Perlmutter Joel S, Parsian Abbas, Guttman Mark, Nicholson Garth, Xu Gang, Wilk Jemma B, Saint-Hilaire Marie H, DeStefano Anita L, Prakash Ranjana, Williamson Sally, Suchowersky Oksana, Labelle Nancy, Growdon John H, Singer Carlos, Watts Ray L, Goldwurm Stefano, Pezzoli Gianni, Baker Kenneth B, Pramstaller Peter P, Burn David J, Chinnery Patrick F, Sherman Scott, Vieregge Peter, Litvan Irene, Gillis Tammy, MacDonald Marcy E, Myers Richard H, Gusella James F
Abstract excerpt
BACKGROUND: The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD). OBJECTIVE: To evaluate the influence of heterozygosity for parkin mutation on onset age in a sample of families with at least 2 PD-affected mem...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.