Article
Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003
Wainwright Mark S, Rossi Janet, Schavocky James, Crawford Susan, Steinhorn David, Velentza Anastasia V, Zasadzki Magdalena, Shirinsky Vladimir, Jia Yuzhi, Haiech Jacques, Van Eldik Linda J, Watterson D Martin
Abstract excerpt
Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule therapeutics. Prevailing hypotheses identify endothelial cell (EC) layer dysfunction as a cardinal event in the pathophysiology, with intracellular protein kinases as critical mediators of normal physiology and possible...
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