Article
A quantitative trait locus influencing fasting plasma glucose in chromosome region 18q22-23.
Diabetes - 1 Sept 2004
Li Wei-Dong, Dong Chuanhui, Li Ding, Garrigan Cathleen, Price R Arlen
Abstract excerpt
Fasting plasma glucose is a multigenic trait related to both diabetes and obesity. We performed a genome scan for quantitative fasting plasma glucose levels in 320 families (1,514 subjects), segregating extreme obesity and normal weight using 382 autosomal microsatellite markers. We found significant linkages on 18q22-23 using family regression (logarithm of odds [LOD] 3.67, P = 0.00002, D18S1371 at 116 cM) and...
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