Article
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.
Human genetics - 1 Sept 1998
Hu Q, Kukull W A, Bressler S L, Gray M D, Cam J A, Larson E B, Martin G M, Deeb S S
Abstract excerpt
The FE65 protein binds to the intracellular domain of the beta-amyloid precursor protein (betaPP) and may modulate the internalization of betaPP. This gene is highly expressed in regions of the brain specifically affected in dementia of the Alzheimer type (DAT). As a prelude to further investigat...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Base Sequence
- Cloning, Molecular
- Dementia
- Exons
- Female
- Humans
- Introns
- Male
- Molecular Sequence Data
- Nerve Tissue Proteins
- Nuclear Proteins
- Polymorphism, Genetic
- Sequence Analysis, DNA
- White People