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Article

p53 mutations and resistance to chemotherapy: A stab in the back for p73.

Cancer cell - 1 Apr 2003

Soussi Thierry

Abstract excerpt

p73 is essential for apoptosis induced by many cytotoxic agents, but this function can be blocked by a particular category of p53 mutations that have consequently acquired a gain of function.

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Topics

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Share to Apoptosis
Share to Cell Transformation, Neoplastic
Share to DNA Damage
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genes, Tumor Suppressor

Share to Tumor Protein p73

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 12726854
DOI: 10.1016/s1535-6108(03)00081-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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