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Article

Targeting p53 for enhanced radio- and chemo-sensitivity.

Apoptosis : an international journal on programmed cell death - 1 Apr 2009

Lu Chao, El-Deiry Wafik S

Abstract excerpt

p53 acts as a central mediator of the cellular response to stressful stimuli. The growth-suppressive function of p53 is lost with mutation and this occurs commonly in human cancer. In addition to suppressing cancer development and progression, wild-type p53 further confers chemo-sensitivity and radio-sensitivity upon tumor cells. Accumulated evidence over the last two decades that wild-type p53 activity is...

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Source

Identifiers

PMID: 19259822
DOI: 10.1007/s10495-009-0330-1

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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