Article
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals.
Nature - 8 May 2003
Montcouquiol Mireille, Rachel Rivka A, Lanford Pamela J, Copeland Neal G, Jenkins Nancy A, Kelley Matthew W
Abstract excerpt
In mammals, an example of planar cell polarity (PCP) is the uniform orientation of the hair cell stereociliary bundles within the cochlea. The PCP pathway of Drosophila refers to a conserved signalling pathway that regulates the coordinated orientation of cells or structures within the plane of an epithelium. Here we show that a mutation in Vangl2, a mammalian homologue of the Drosophila PCP gene Strabismus/Van...
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