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Article

Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.

Microbiology (Reading, England) - 1 May 2003

Rawat Mamta, Kovacevic Svetozar, Billman-Jacobe Helen, Av-Gay Yossef

Abstract excerpt

The mshB gene encoding N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. Disruption of mshB in Mycobacterium smegmatis resulted in decreased production of mycothiol (5-10 % of the parent strain mc(2)155) but did not abolish mycothiol synthesis completely. Complementation of the MshB(-) mutants with the mshB gene resulted in increased...

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PMID: 12724395
DOI: 10.1099/mic.0.26084-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.PMID 12724395Read ↗

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