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Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Microbiology and molecular biology reviews : MMBR - 1 Sept 2008

Newton Gerald L, Buchmeier Nancy, Fahey Robert C

Abstract excerpt

Mycothiol (MSH; AcCys-GlcN-Ins) is the major thiol found in Actinobacteria and has many of the functions of glutathione, which is the dominant thiol in other bacteria and eukaryotes but is absent in Actinobacteria. MSH functions as a protected reserve of cysteine and in the detoxification of alkylating agents, reactive oxygen and nitrogen species, and antibiotics. MSH also acts as a thiol buffer which is...

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Identifiers

PMID: 18772286
DOI: 10.1128/MMBR.00008-08
PMCID: PMC2546866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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