Article
Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production.
Journal of bacteriology - 1 Oct 2007
Bzymek Krzysztof P, Newton Gerald L, Ta Philong, Fahey Robert C
Abstract excerpt
Mycothiol ([MSH] AcCys-GlcN-Ins, where Ac is acetyl) is the major thiol produced by Mycobacterium smegmatis and other actinomycetes. Mutants deficient in MshA (strain 49) or MshC (transposon mutant Tn1) of MSH biosynthesis produce no MSH. However, when stationary phase cultures of these mutants were incubated in medium containing MSH, they actively transported it to generate cellular levels of MSH comparable to...
Topics
- Acetylcysteine
- Carbon Radioisotopes
- Cysteine
- Glycopeptides
- Inositol
- Inositol Phosphates
- Models, Biological
- Molecular Structure
- Mutation
- Mycobacterium smegmatis
- Pyruvic Acid