Article
Base composition analysis of human mitochondrial DNA using electrospray ionization mass spectrometry: a novel tool for the identification and differentiation of humans.
Analytical biochemistry - 1 Sept 2005
Hall Thomas A, Budowle Bruce, Jiang Yun, Blyn Lawrence, Eshoo Mark, Sannes-Lowery Kristin A, Sampath Rangarajan, Drader Jared J, Hannis James C, Harrell Patina, Samant Vivek, White Neill, Ecker David J, Hofstadler Steven A
Abstract excerpt
In traditional approaches, mitochondrial DNA (mtDNA) variation is exploited for forensic identity testing by sequencing the two hypervariable regions of the human mtDNA control region. To reduce time and labor, single nucleotide polymorphism (SNP) assays are being sought to possibly replace sequencing. However, most SNP assays capture only a portion of the total variation within the desired regions, require a...
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