Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Von Willebrand factor promoter targets the expression of amyloid β protein precursor to brain vascular endothelial cells of transgenic mice

22 Apr 2003

Abstract excerpt

Dysfunction of brain vascular endothelial cells may be associated with the pathogenesis of several diseases including cerebral amyloid angiopathy, hemorrhagic stroke and Alzheimer disease. New model systems are necessary to examine the contribution of brain endothelial cells in these disorders. The Von Willebrand factor gene promoter fragment that spans sequences -487 to +247 targets the expression of LacZ marker...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cancer-related gene regulation
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12719632
DOI: 10.3233/jad-2003-5209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Von Willebrand factor promoter targets the expression of amyloid β protein precursor to brain vascular endothelial cells of transgenic micePMID 12719632Read ↗

Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice.Semantic proximity Read ↗

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.Semantic proximity Read ↗

Endothelial expression of human APP leads to cerebral amyloid angiopathy in miceSemantic proximity Read ↗

Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Semantic proximity Read ↗

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.Semantic proximity Read ↗

Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosisSemantic proximity Read ↗

Mechanisms of Cerebrovascular Amyloid Deposition: Lessons from Mouse ModelsSemantic proximity Read ↗

Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells.Semantic proximity Read ↗

Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.Semantic proximity Read ↗

Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy.Semantic proximity Read ↗

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor.Semantic proximity Read ↗

Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.