Article
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor.
The Journal of biological chemistry - 7 May 2004
Davis Judianne, Xu Feng, Deane Rashid, Romanov Galina, Previti Mary Lou, Zeigler Kelly, Zlokovic Berislav V, Van Nostrand William E
Abstract excerpt
Cerebrovascular deposition of amyloid beta-protein (Abeta) is a common pathological feature of Alzheimer's disease and related disorders. In particular, the Dutch E22Q and Iowa D23N mutations in Abeta cause familial cerebrovascular amyloidosis with abundant diffuse amyloid plaque deposits. Both o...
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