Article
A genomic screen for yeast mutants defective in selective mitochondria autophagy.
Molecular biology of the cell - 1 Nov 2009
Kanki Tomotake, Wang Ke, Baba Misuzu, Bartholomew Clinton R, Lynch-Day Melinda A, Du Zhou, Geng Jiefei, Mao Kai, Yang Zhifen, Yen Wei-Lien, Klionsky Daniel J
Abstract excerpt
Mitophagy is the process of selective mitochondrial degradation via autophagy, which has an important role in mitochondrial quality control. Very little is known, however, about the molecular mechanism of mitophagy. A genome-wide yeast mutant screen for mitophagy-defective strains identified 32 mutants with a block in mitophagy, in addition to the known autophagy-related (ATG) gene mutants. We further...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.