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Article

Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.

Genetics - 1 Aug 2007

Zurita-Martinez Sara A, Puria Rekha, Pan Xuewen, Boeke Jef D, Cardenas Maria E

Abstract excerpt

The Tor kinases regulate responses to nutrients and control cell growth. Unlike most organisms that only contain one Tor protein, Saccharomyces cerevisiae expresses two, Tor1 and Tor2, which are thought to share all of the rapamycin-sensitive functions attributable to Tor signaling. Here we conducted a genetic screen that defined the global TOR1 synthetic fitness or lethal interaction gene network. This screen...

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Identifiers

PMID: 17565946
DOI: 10.1534/genetics.107.072835
PMCID: PMC1950620

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