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Article

Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.

The Journal of biological chemistry - 6 Aug 2004

Mishima Masaki, Sakai Yasunari, Itoh Noriyuki, Kamiya Hiroyuki, Furuichi Masato, Takahashi Masayuki, Yamagata Yuriko, Iwai Shigenori, Nakabeppu Yusaku, Shirakawa Masahiro

Abstract excerpt

Oxygen radicals generated through normal cellular respiration processes can cause mutations in genomic and mitochondrial DNA. Human MTH1 hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-dATP, to monophosphates, thereby preventing the misincorporation of these oxidized nucleotides during replication. Here we present the solution structure of MTH1 solved by multidimensional...

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PMID: 15133035
DOI: 10.1074/jbc.M402393200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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