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Article

Genetic defects in the development and function of the anterior pituitary gland.

Annals of medicine - 1 Jan 2002

Cushman Lisa J, Showalter Aaron D, Rhodes Simon J

Abstract excerpt

Genetic defects affecting the hypothalamic-pituitary-target organ axes can cause a variety of diseases involving restricted or broad disruptions of human development and physiology. At the level of the anterior pituitary gland, mutations in the genes encoding key transcription factors, hypothalamic releasing and inhibiting hormone receptors, and the pituitary hormones themselves, can all result in the loss of...

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Topics

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Share to Homeobox Protein PITX2
Share to Hypothalamo-Hypophyseal System
Share to LIM-Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pituitary Gland, Anterior

Share to Receptors, Pituitary Hormone-Regulating Hormone

Share to RNA Splicing Factors

Share to Transcription Factor HES-1

Share to Transcription Factor Pit-1

Source

Identifiers

PMID: 12173688

Genes

HESX1
LHX3
LHX4
PITX2
PROP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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