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Article

Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway.

American journal of physiology. Lung cellular and molecular physiology - 1 Mar 2022

Shaughnessy Ciaran A, Yadav Sangya, Bratcher Preston E, Zeitlin Pamela L

Abstract excerpt

Cystic fibrosis (CF) is a genetic disease caused by mutations of the gene encoding a cAMP-activated Cl- channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR modulator therapies consist of small-molecule drugs that rescue mutant CFTR. Regimens of single or combinations of CFTR modulators still rely on endogenous levels of cAMP to regulate CFTR activity. We investigated CFTR activation by...

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Identifiers

PMID: 35020527
DOI: 10.1152/ajplung.00388.2021
PMCID: PMC8858663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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