Article
Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3-.
The American journal of physiology - 1 Dec 1998
Illek B, Fischer H, Machen T E
Abstract excerpt
Cystic fibrosis (CF) affects a number of epithelial tissues, including those in the gastrointestinal tract. The goal of this review is to summarize data related to regulation of the protein product of the CF gene, CF transmembrane conductance regulator (CFTR), by a variety of small molecules. There has been a surge of interest in discovering small molecules that could be exogenously added to cells and tissues to...
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