Article
Structural elements in the internal ribosome entry site of Plautia stali intestine virus responsible for binding with ribosomes.
Nucleic acids research - 1 May 2003
Nishiyama Takashi, Yamamoto Hiroshi, Shibuya Norihiro, Hatakeyama Yoshinori, Hachimori Akira, Uchiumi Toshio, Nakashima Nobuhiko
Abstract excerpt
Plautia stali intestine virus (PSIV) has an internal ribosome entry site (IRES) at the intergenic region of the genome. The PSIV IRES initiates translation with glutamine rather than the universal methionine. To analyze the mechanism of IRES-mediated initiation, binding of IRES RNA to salt-washed ribosomes in the absence of translation factors was studied. Among the three pseudoknots (PKs I, II and III) within...
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