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Article

Ribosomal binding to the internal ribosomal entry site of classical swine fever virus

1 Dec 2000

Abstract excerpt

Most eukaryotic mRNAs require the cap-binding complex elF4F for efficient initiation of translation, which occurs as a result of ribosomal scanning from the capped 5' end of the mRNA to the initiation codon. A few cellular and viral mRNAs are translated by a cap and end-independent mechanism known as internal ribosomal entry. The internal ribosome entry site (IRES) of classical swine fever virus (CSFV) is...

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PMID: 11142379
DOI: 10.1017/s1355838200000662

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