Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene.

Developmental biology - 1 May 2003

Aota Shin-ichi, Nakajima Noboru, Sakamoto Ruriko, Watanabe Sonoe, Ibaraki Nobuhiro, Okazaki Kenji

Abstract excerpt

The Pax6 gene plays crucial roles in eye development and encodes a transcription factor containing both a paired domain and a homeodomain. During embryogenesis, Pax6 is expressed in restricted tissues under the direction of distinct cis-regulatory regions. The head surface ectoderm-specific enhancer of mouse Pax6 directs reporter expression in the derivatives of the ectoderm in the eye, such as lens and cornea,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ectoderm
Share to Head

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High Mobility Group Proteins

Share to HMGB Proteins

Share to Lens, Crystalline

Share to Paired Box Transcription Factors

Share to PAX6 Transcription Factor

Share to SOXB1 Transcription Factors

Source

Identifiers

PMID: 12710953
DOI: 10.1016/s0012-1606(03)00058-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene.PMID 12710953Read ↗

Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain.Semantic proximity Read ↗

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.Semantic proximity Read ↗

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.Semantic proximity Read ↗

PAX6, paired domain influences sequence recognition by the homeodomain.Semantic proximity Read ↗

Unique functions of two overlapping <i>PAX6</i> retinal enhancersSemantic proximity Read ↗

Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and DiseaseSemantic proximity Read ↗

The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid.Semantic proximity Read ↗

MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling.Semantic proximity Read ↗

A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye.Semantic proximity Read ↗

Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases.Semantic proximity Read ↗

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.Semantic proximity Read ↗

Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.