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Article

MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling.

The EMBO journal - 2 Jun 2014

Bhinge Akshay, Poschmann Jeremie, Namboori Seema C, Tian Xianfeng, Jia Hui Loh Sharon, Traczyk Anna, Prabhakar Shyam, Stanton Lawrence W

Abstract excerpt

Several transcription factors (TFs) have been implicated in neuroectoderm (NE) development, and recently, the TF PAX6 was shown to be critical for human NE specification. However, microRNA networks regulating human NE development have been poorly documented. We hypothesized that microRNAs activated by PAX6 should promote NE development. Using a genomics approach, we identified PAX6 binding sites and active...

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Source

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Identifiers

PMID: 24802670
DOI: 10.1002/embj.201387215
PMCID: PMC4198029

Genes

PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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