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Article

Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice.

Psychopharmacology - 1 Aug 2003

Raud Sirli, Rünkorg Kertu, Veraksits Alar, Reimets Ain, Nelovkov Aleksei, Abramov Urho, Matsui Toshimitsu, Bourin Michel, Volke Vallo, Kõks Sulev, Vasar Eero

Abstract excerpt

RATIONALE: Evidence suggests that GABA and CCK have opposite roles in the regulation of anxiety. OBJECTIVE: The aim of the present work was to study diazepam-induced anxiolytic-like action and impairment of motor co-ordination, and the parameters of benzodiazepine receptors in mice lacking CCK2 receptors. METHODS: The action of diazepam (0.5-3 mg/kg i.p.) was studied in the elevated plus-maze model of anxiety and...

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Identifiers

PMID: 12709779
DOI: 10.1007/s00213-003-1453-7

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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