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Article

Structural consequences of mutations in interfacial Tyr residues of a protein antigen-antibody complex. The case of HyHEL-10-HEL.

The Journal of biological chemistry - 2 Mar 2007

Shiroishi Mitsunori, Tsumoto Kouhei, Tanaka Yoshikazu, Yokota Akiko, Nakanishi Takeshi, Kondo Hidemasa, Kumagai Izumi

Abstract excerpt

Tyrosine is an important amino acid in protein-protein interaction hot spots. In particular, many Tyr residues are located in the antigen-binding sites of antibodies and endow high affinity and high specificity to these antibodies. To investigate the role of interfacial Tyr residues in protein-pr...

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PMID: 17166830
DOI: 10.1074/jbc.M605197200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17166830-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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