A versatile denaturing HPLC approach for human beta-globin gene mutation screening.

doi:10.1002/ajh.20723

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Article

A versatile denaturing HPLC approach for human beta-globin gene mutation screening.

American journal of hematology - 1 Feb 2007

Bournazos Stavros N, Tserga Aggeliki, Patrinos George P, Papadakis Manoussos N

Abstract excerpt

Hemoglobinopathies represent the most common genetic disorder worldwide, with a higher prevalence among populations with a history of malaria endemicity. More than 690 mutations in the human beta-globin gene are usually the cause of beta-type hemoglobinopathies. Here, we report a rapid and highly sensitive beta-globin gene mutation screening approach based on denaturing high-performance liquid chromatography...

Topics

Chromatography, High Pressure Liquid
DNA Mutational Analysis
Female
Genetic Testing
Globins
Greece
Humans
Male
Mutation
Nucleic Acid Denaturation
beta-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 16924651
DOI: 10.1002/ajh.20723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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