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Article

Is hemochromatosis a risk factor for Alzheimer's disease?

30 Sept 2001

Abstract excerpt

Excess iron accumulation in the brain is a consistent observation in Alzheimer's Disease. Iron affects amyloid precursor protein (AbetaPP) processing and promotes deposition of Abeta. Iron is also among the most potent biological toxins because of its ability to react with oxygen to form reactive oxygen species. Consequently, elucidation of the mechanisms associated with maintaining brain iron homeostasis is...

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Identifiers

PMID: 12214033
DOI: 10.3233/jad-2001-3506

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