Article
Rapid genotyping of common MeCP2 mutations with an electronic DNA microchip using serial differential hybridization.
The Journal of molecular diagnostics : JMD - 1 May 2003
Thistlethwaite William A, Moses Linda M, Hoffbuhr Kristen C, Devaney Joseph M, Hoffman Eric P
Abstract excerpt
Rett syndrome is a neurodevelopmental disorder that affects females almost exclusively, and in which eight common point mutations on the X-linked MeCP2 gene are knows to cause over 70% of mutation-positive cases. We explored the use of a novel platform to detect the eight common mutations in Rett syndrome patients to expedite and simplify the process of identification of known genotypes. The Nanogen workstation...
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