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Article

Rapid parallel mutation scanning of gene fragments using a microelectronic protein-DNA chip format.

Nucleic acids research - 15 Jul 2002

Behrensdorf Heike A, Pignot Marc, Windhab Norbert, Kappel Andreas

Abstract excerpt

We have developed a method for the de novo discovery of genetic variations, including single nucleotide polymorphisms and mutations, on microelectronic chip devices. The method combines the features of electronically controlled DNA hybridisation on open-format microarrays, with mutation detection by a fluorescence-labelled mismatch- binding protein. Electronic addressing of DNA strands to distinct test sites of...

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Identifiers

PMID: 12136112
DOI: 10.1093/nar/gnf063
PMCID: PMC135765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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